Author

Pedro Henrique Gazzinelli-Guimarães

National Institutes of HealthORCID 0000-0003-4932-2206Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1

Frequent Co-Authors

Fabrício Marcus Silva OliveiraiD· 2 shared Sundar GanesaniD· 2 shared Tiago Rodrigues FerreiraiD· 2 shared Alejandro V. VillarinoiD· 1 shared Aline Sardinha-SilvaiD· 1 shared Andrea PauniD· 1 shared Anthony C. CruziD· 1 shared Behdad AfzaliiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersImmunology

Fabrício Marcus Silva OliveiraORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

ImmunologyThe Journal of Experimental MedicinePeer-reviewedJan 17, 2026

A PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4+ T helper cell signaling, differentiation and epigenetic remodeling

Dominic P. Golec, Pedro Henrique Gazzinelli-Guimarães, Daniel Chauss…·Pamela L. Schwartzberg

The paper identifies a PI3Kδ-Foxo1-FasL signaling loop that disrupts Th2 differentiation and epigenetic regulation in CD4+ T cells.

1 citation

mousebulk RNA-seq

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ImmunologyNature MicrobiologyPeer-reviewedJul 8, 2025

Giardia intestinalis reshapes mucosal immunity toward a Type 2 response that attenuates inflammatory bowel-like diseases

Aline Sardinha-Silva, Pedro Henrique Gazzinelli-Guimarães, Oluwaremilekun Grace Ajakaye…·Michael E. Grigg

This study shows Giardia intestinalis induces a Type 2 immune response that reduces inflammation in the gut, protecting against inflammatory bowel-like diseases.

29 citationstop 1%

humanexperimental assay

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ImmunologyNature CommunicationsPeer-reviewedApr 1, 2025

Kupffer cell and recruited macrophage heterogeneity orchestrate granuloma maturation and hepatic immunity in visceral leishmaniasis

Gabriela Pessenda, Tiago Rodrigues Ferreira, Andrea Paun…·David L. Sacks

The paper shows that macrophage heterogeneity, including resKC-derived and monocyte-derived cells, is critical for granuloma maturation and parasite control in visceral leishmaniasis.

26 citationstop 1%

mousebulk RNA-seq

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