Kevin G. Chen

This study characterizes a new pluripotent state in RSeT hESCs, showing resistance to naive and formative conversion and distinct transcriptomic and signaling features.

This study identifies a unique metabolic state in RSeT human embryonic stem cells characterized by quadrivalency, linking it to growth independence from oxygen and resistance to naive reprogramming.

This paper performs a multivariate meta-analysis of human pluripotent stem cell datasets to assess the existence of a naive pluripotent state, finding inconsistencies and no clear transcriptomic markers for a bona fide human naive state.

The paper performs a multivariate meta-analysis of human pluripotent stem cell datasets to assess interlaboratory variability in defining naive-like pluripotent states.