Yixin Zhang

This paper identifies APOE-ϵ4-induced fibronectin accumulation at the blood-brain barrier as a key mediator of astrocyte-endothelial dysfunction in Alzheimer's disease, highlighting it as a potential therapeutic target.

The paper quantitatively analyzes individual ligation reactions in DNA origami nanostructures using qPCR, revealing edge preference and solvent-dependent behavior.

This paper introduces a DNA steganography method that uses randomness, secondary secret keys, and self-destruction to enhance data security.

The paper uses single-cell transcriptomics to analyze how Amyloid-beta42 and Interleukin-4 affect neural stem/progenitor cell plasticity in adult zebrafish brain, identifying gene expression changes and cell-cell communication alterations.

This study shows that IL4 restores neurogenic plasticity of human NSCs by suppressing KAT2, which is upregulated in AD mouse models.

The paper introduces an RT-PCR-based method to model large, dynamic, and heterogeneous populations using DNA libraries, demonstrating applications in drug discovery and population dynamics.

This paper introduces a 3D hydrogel culture system to model human neural stem cell plasticity, neurogenesis, and neurodegeneration, showing improved neuronal maturation and disease modeling.