Bin Wu

A bipolar disorder-associated ultra-rare AKAP11 protein-truncating variant attenuates stimulus-dependent PKA activation and induces anxiety- and depression-related behaviors in mice

This study introduces an ultra-rare AKAP11 protein-truncating variant in mice, showing it causes anxiety- and depression-like behaviors and disrupts PKA signaling.

A Rapid Inducible RNA Decay system reveals fast mRNA decay in P-bodies

This study introduces a method to rapidly induce RNA decay and shows that mRNAs decay quickly in P-bodies.

Bidirectional transcription at the PPP2R2B gene locus in spinocerebellar ataxia type 12

This study identifies bidirectional transcription at the PPP2R2B gene locus in SCA12 and shows that expanded antisense transcripts are toxic and contribute to disease pathogenesis.

Bursting Translation on Single mRNAs in Live Cells

The paper tracks single mRNA translation in live cells, revealing that translation occurs in bursts and is influenced by 5' UTR structure and environmental signals.

Dynamin is primed at endocytic sites for ultrafast endocytosis

The paper shows that Dynamin 1xA forms molecular condensates with Syndapin 1 at endocytic sites, enabling ultrafast endocytosis by bypassing the recruitment step.

Dynamin forms liquid-like condensates at synapses to support ultrafast endocytosis

The paper shows that Dynamin 1xA and Syndapin 1 form liquid-like condensates at synapses, which facilitate ultrafast endocytosis by enabling molecular crowding and intermolecular interactions.

Spatial organization of single mRNPs at different stages of the gene expression pathway

The paper investigates mRNP organization and shows that mRNA compaction changes with translational state and that mRNAs are not translated in a closed-loop conformation.

Synergy of Quorum Quenching Enzyme and Quorum Sensing Inhibitor in Inhibiting P. aeruginosa Quorum Sensing

This study shows that combining a quorum quenching enzyme and a quorum sensing inhibitor effectively blocks Pseudomonas aeruginosa quorum sensing.

Cyclic-di-GMP is required for corneal infection by Pseudomonas aeruginosa and modulates host immunity

This study shows that c-di-GMP is essential for Pseudomonas aeruginosa biofilm formation in vivo and impairs host immunity during corneal infection.