Jan Kaslin

This paper introduces Airy beam light sheet microscopy to image subcellular dynamics in large tissues with high spatial and temporal resolution across multiple organisms and biological processes.

The paper presents an optimized Halo-seq protocol to profile nucleoplasmic and nucleolar RNAs in HeLa cells, demonstrating high spatial specificity.

This paper identifies Ca2+-mediated protein citrullination as a regulator of neural stem cell proliferation in CNS regeneration and cancer, showing PAD inhibitors suppress medulloblastoma growth.

dirCLIP uses nanopore sequencing to profile variant-specific RNA-protein interactions, revealing isoform-selective binding and co-occurring sites with high concordance to short-read data.

The paper uses a zebrafish model of MPS IIIA to identify synaptic activity deficiencies as a key driver of disease progression through systems-level omics analyses and a novel bioinformatic tool.

This study develops a zebrafish model for CDKL5 Deficiency Disorder to investigate disease mechanisms and screen for therapies.

This study shows that lrrk2 knockout in zebrafish causes dopamine and serotonin catabolism changes, reduced cell proliferation, and impaired neuronal regeneration.

This study identifies two phases of cellular regeneration after spinal cord injury in zebrafish, highlighting the role of precursor neuron migration in initiating functional recovery.

This study uses a zebrafish model of familial Alzheimer’s disease to show accelerated brain aging and transcriptional inversion linked to glucocorticoid resistance and immune pathway changes before histopathology.

This study investigates the regenerative capacity of quiescent radial-glial stem cells in the zebrafish tectum, showing that lesion-induced proliferation and neurogenesis occur through distinct progenitor populations and are Wnt-independent.