Ethanol induces neuroimmune dysregulation and soluble TREM2 generation in a human iPSC neuron, astrocyte, microglia triculture model
Andrew J. Boreland, Yara Abbo, Xindi Li…·Ronald P. Hart
This study shows ethanol exposure in a human iPSC-derived triculture model increases TREM2 expression and soluble TREM2 through alternative splicing, suggesting a link to neuroimmune dysregulation in alcohol use disorders.