Peng Jiang

This study uses human brain organoids to show that transient IL-6 exposure during prenatal development disrupts interneuron maturation and subtype specification, linking it to neurodevelopmental disorders.

This study shows that NEUROG2 can reprogram human microglial lineage cells into neurons both in vitro and in vivo, revealing a new pathway for neuronal replacement.

This study develops a method to generate diverse GABAergic neurons from PSCs using TFs and signaling inhibition, showing distinct subtype compositions and disease relevance.

CGPA provides a platform for multi-context gene-centric prognostic analysis, enabling customized exploration of gene relationships and biomarker discovery in cancer research.

This study uses human-mouse chimeric brain models to investigate glial-neuronal and macroglial-microglial interactions, revealing key molecular mechanisms and dynamic cellular behaviors.

This paper introduces a trisomy 21-linked CSF2RB mutation in microglia that reduces neuroinflammation and enhances phagocytic functions, offering potential for AD therapy.

This study shows HIV-1 infects human iPSC-derived microglia, causing sustained type I interferon signaling and disease risk gene expression in a neural model.

The paper investigates the impact of the NLGN3 R451C mutation on human neurons, finding it reduces protein levels but enhances excitatory synapses, potentially contributing to ASD pathogenesis.

This study develops a human brain organoid model with controllable microglia ratios to better model brain development and pathology.

This study xenotransplants human PSC-derived microglia into mice to create a chimeric brain model that retains human microglial identity and exhibits disease-relevant responses.

This study shows that OLIG2 overexpression in Down syndrome patient-derived iPSCs leads to abnormal neurodevelopmental phenotypes, including impaired recognition memory in chimeric mice.

This study uses human pluripotent stem cell-derived cerebral organoids to show that oligodendrogenesis in the human brain has both ventral and dorsal origins, with dorsal cells dominating in fused organoids.