Ya–Wen Chen

This study generates region-specific airway basal stem cells from human pluripotent stem cells by modulating the NOGGIN-BMP axis, showing distinct differentiation potentials for proximal and distal airway cell types.

The paper identifies a novel APOE+ elastin-producing valve interstitial cell subtype and reveals the APOE-NOTCH signaling axis regulates elastogenesis during human cardiac valve remodeling.

This study identifies epigenetic reprogramming defects in preeclampsia placenta that cause developmental delay and can be detected in serum cfDNA for early prediction.