Cheng Qian

Lignature is a database of ligand-induced transcriptomic signatures that improves prediction of active ligands compared to existing methods like NicheNet.

This study investigates the roles of Kdm6a and Kdm6b in neural regeneration, finding they regulate axon regeneration and RGC survival with distinct mechanisms and identifying Klf4 as a downstream target.

MetaLigand predicts non-peptide ligand-receptor interactions using transcriptomic data, revealing unique NPL profiles in retinal cell types associated with age-related macular degeneration.

The paper constructs an intercellular communication atlas of the retina, identifying Oprm1 as a neuroprotective factor that enhances RGC survival through ligand-receptor interactions.