Ying Xin

Lignature: A Comprehensive Database of Ligand Signatures to Predict Cell-Cell Communication

Lignature is a database of ligand-induced transcriptomic signatures that improves prediction of active ligands compared to existing methods like NicheNet.

Attenuated adenosine mediated immune-dampening increases natural killer cell activity in early age-related macular degeneration

The paper investigates immune alterations in early AMD, finding elevated NK cell activity and reduced adenosine, suggesting immune imbalance drives disease progression.

MetaLigand: A database for predicting non-peptide ligand mediated cell-cell communication

MetaLigand predicts non-peptide ligand-receptor interactions using transcriptomic data, revealing unique NPL profiles in retinal cell types associated with age-related macular degeneration.

Intercellular communication atlas reveals Oprm1 as a neuroprotective factor for retinal ganglion cells

The paper constructs an intercellular communication atlas of the retina, identifying Oprm1 as a neuroprotective factor that enhances RGC survival through ligand-receptor interactions.

LRLoop: Feedback loops as a design principle of cell-cell communication

LRLoop identifies bidirectional ligand-receptor feedback loops in cell-cell communication, reducing false positives and revealing new interactions in retinal development.