Michael S. Kay

The paper reveals how phosphorylation of SMO in the Hedgehog pathway stabilizes a conformation that inhibits PKA-C, providing a structural mechanism for noncanonical GPCR signaling.

This paper develops a stabilized MERS-CoV spike ferritin nanoparticle vaccine that elicits strong neutralizing antibodies in mice and non-human primates, providing protection against MERS-CoV infection.

The paper identifies a divergent cytochrome c in malaria parasites with an unusually low redox potential, suggesting a novel biochemical role outside the canonical electron transport chain function.

The paper uses electron tomography to visualize HIV-1 virions trapped by fusion inhibitors in infected tissues, revealing pre-hairpin intermediates linked to host cells.