This paper introduces antiGen, a machine learning model that forecasts viral mutations from phylogenetic trees, achieving state-of-the-art results for SARS-CoV-2 and other viruses.

bioRxiv · Sep 5, 2026 · PreprintEvolutionary Biology

A stabilized MERS-CoV spike ferritin nanoparticle vaccine elicits robust and protective neutralizing antibody responses

Abigail E. Powell, Hannah Caruso, Soyoon Park, Jui‐Lin Chen, Jessica O’Rear, Brian Ferrer, Daniel J Stieh, Adam M. Weiss, David M. Belnap, Audrey Walker, Anneliese Bruening, Airn E. Hartwig, Kaitlin R. Sprouse, Amin Addetia, Abeer N. Alshukairi, , Brad A. Palanski

This paper develops a stabilized MERS-CoV spike ferritin nanoparticle vaccine that elicits strong neutralizing antibodies in mice and non-human primates, providing protection against MERS-CoV infection.

Nature Communications · Feb 5, 2026Peer-reviewedBiochemistry

Design, Structure, and Immunogenicity of a Soluble Prefusion-stabilized EBV gB Antigen

Ryan S. McCool, Cory M. Acreman, Abigail E. Powell, Sofia I. Picucci, Daniel J Stieh, Jeremy Huynh, Hannah Caruso, Soyoon Park, Jessica O’Rear, Jui‐Lin Chen, Brad A. Palanski, Patrick O. Byrne, Madeline R. Sponholtz, Chia‐Wei Chou, Jeongryeol Kim, , Jason S. McLellan

This study designs and characterizes a prefusion-stabilized EBV gB antigen, showing improved immunogenicity and structural insights for vaccine development.

bioRxiv · May 19, 2025 · PreprintBiochemistry

Quantitative and temporal measurement of dynamic autophagy rates

Nitin Sai Beesabathuni, Soyoon Park, Priya S. Shah

This paper develops a framework to measure autophagy rates under non-steady state conditions and applies it to study temporal responses to rapamycin and wortmannin treatments.

Autophagy · Aug 26, 2022Peer-reviewedSystems Biology