Aofei Liu

This paper demonstrates targeted protein relocalization using shuttle proteins and small molecules to redistribute disease-associated proteins and alleviate cellular stress and neurodegeneration.

The paper shows that ERES segregate based on cargo size, with bulky cargoes accumulating less at stalled ERES compared to small molecules.

This paper constructs light-activated neurotrophin receptors using the iLID system and demonstrates their ability to reproduce downstream signaling in response to blue light.

This paper develops optogenetic systems to precisely control nanoscale membrane curvature in live cells using engineered BAR domain proteins.

This paper develops optogenetic methods to activate TrkB receptors with spatial and temporal control, finding that the CRY2-based approach is most efficient.