BiochemistrybioRxivPreprint
Cryo-EM structure of human LRRC15 reveals the basis of therapeutic antibody recognition
Xiaomin Wang, Mihin Perera, Maryam Sana…·Shabih Shakeel
The paper determines the cryo-EM structure of LRRC15 and identifies the epitope recognized by the antibody samrotamab, revealing a binding mode that preserves signaling surfaces.