Astrocyte CB1 receptors drive blood-brain barrier disruption in CNS inflammatory disease
Teresa Colomer, Ester Sánchez-Martín, Ana Bernal‐Chico, A. Moreno‐García, Román Serrat, Andrés M. Baraibar, Aitziber Uribe-Irusta, Ander Iriarte-Sarria, Urszula Skupio, Carlos Matute, Vanja Tepavčević, Ignacio Fernández‐Moncada, Candice Chapouly, Giovanni Marsicano, Susana Mato
This study shows that astrocyte CB1R signaling promotes inflammation in MS by disrupting the blood-brain barrier and reducing BBB function.
bioRxiv · Jun 23, 2025 · PreprintNeuroscience