Lori A. Coburn

The paper performs single-cell transcriptome-wide association analysis to identify cell-type-specific genetic susceptibility genes for colorectal cancer, finding 546 gene-cell-type associations and 347 candidate susceptibility genes.

This paper evaluates the statistical validity of synthetic biomedical images and introduces PAMS to improve biological inference.

The paper presents the Human Gut Cell Atlas v1.0, a unified reference of gut cell diversity, revealing how tissue structure influences cellular composition and enabling disease and organoid analysis.

The paper identifies a pathobiont-epithelial IDO1 pathway that drives region-specific susceptibility to inflammatory bowel disease in the ascending colon.

The paper identifies a novel epithelial cell type, LND, in Crohn's disease that is associated with immune dysregulation and disease activity.

The paper develops a translation model to identify integrin signaling in anti-TNF-resistant Crohn’s disease and validates it using single-cell RNA sequencing.