André Monteiro da Rocha

This study shows that lead exposure during iPSC-derived cardiomyocyte differentiation affects electrophysiological properties in a cell line- and concentration-dependent manner, with effects persisting after exposure ends.

This study shows that PFOA exposure during cardiomyocyte differentiation alters gene expression and electrophysiological function in hiPSC-CM, with effects lasting after exposure stops.

This study shows that lead exposure during human iPSC-derived cardiomyocyte differentiation alters gene expression and pathway dysregulation, with persistent transcriptional changes even after exposure stops.

The paper uses donor-matched iPSC-derived FAPs to show that T2D GWAS signals are enriched in adipogenic FAP subtypes under high-insulin exposure.

This study shows that diet-induced obesity paradoxically increases SERCA activity in atrial myocytes, contributing to atrial fibrillation through altered Ca2+ dynamics.

This study uses hiPSC-derived atrial cardiomyocytes and fibroblasts to model atrial fibrillation through intermittent tachypacing, showing increased AP frequency and fibrosis markers.

This study reactivates FMR1 transcription in FXS patient cells using CRISPR/dCAS9 and VP192, increasing FMRP levels and demonstrating a potential therapeutic approach for Fragile X Syndrome.