Misa Hirose

Proteo-transcriptomic reprogramming and resource reallocation define the aging mammalian brain

This study identifies molecular signatures of aging in the mouse brain through proteo-transcriptomic analysis, revealing changes in protein aggregation, mRNA relocalization, and translation efficiency linked to neurodegeneration.

Mitochondrial haplotype and mito-nuclear matching drive somatic mutation and selection throughout aging

The paper examines how mitochondrial haplotype and mito-nuclear matching influence somatic mutation and selection in aging mice across tissues.

North and East African mitochondrial genetic variation needs further characterization towards precision medicine

The paper characterizes mitochondrial genetic variation in North and East Africa, identifying novel haplogroups and phylogenetic deviations.

Loss of p32 triggers energy deficiency and impairs goblet cell differentiation in ulcerative colitis

The paper shows that loss of p32 leads to energy deficiency and impaired goblet cell differentiation in ulcerative colitis, suggesting nutritional intervention could prevent this.

An integrated personal and population-based Egyptian genome reference

The paper presents the first de novo assembled Egyptian genome and population-based genetic variation data, highlighting differences in allele frequencies and linkage disequilibrium between Egyptians and Europeans.

Maternally inherited differences within mitochondrial Complex I control murine healthspan.

This study shows that a mutation in mt-Nd2, a mitochondrial complex I gene, reduces lifespan and increases glucose intolerance in mice by affecting tryptophan levels and aging pathways.

Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice

This study shows that high mitochondrial heteroplasmy in mice reduces lifespan and impairs glucose metabolism.