Author

Jordan M Mancl

University of ChicagoORCID 0000-0003-3368-6275Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:cryo-EM· 2 Approach:deep learning· 2 Approach:mechanistic / dynamical model· 2 Research Focus:protein folding & dynamics· 2 Organism:human· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Wei‐Jen TangiD· 2 shared Bridget CarragheriD· 1 shared Clinton S PotteriD· 1 shared Hui Alex WeiiD· 1 shared Joshua H. MendeziD· 1 shared Minglei ZhaoiD· 1 shared Nicholas L BayhiiD· 1 shared Tobin R. SosnickiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiophysics

Wei‐Jen TangORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

BiophysicsbioRxivJan 9, 2025

Dimerization and dynamics of angiotensin-I converting enzyme revealed by cryo-EM and MD simulations

Jordan M Mancl, Xiaoyang Wu, Minglei Zhao, Wei‐Jen Tang

The paper reports the cryo-EM structure of full sACE dimer and uses MD simulations to study its conformational dynamics and domain-specific behavior.

2 citations

cryo-EMdeep learning

𝕏 PostBluesky

BiophysicsbioRxivDec 30, 2024

Characterization and modulation of human insulin degrading enzyme conformational dynamics to control enzyme activity

Jordan M Mancl, Wenguang G. Liang, Nicholas L Bayhi…·Wei-Jen Tang

This study characterizes IDE conformational dynamics using cryo-EM and MD simulations, identifying key residues and mechanisms that modulate enzyme activity.

DOI 10.7554/elife.105761

𝕏 PostBluesky