Christophe Paget

Hijacking of inflammasome responses by the complement system during Pseudomonas aeruginosa-Aspergillus fumigatus sur-infection

This study identifies a complement-inflammasome signaling axis that drives excessive inflammation during Pseudomonas aeruginosa and Aspergillus fumigatus co-infection in cystic fibrosis patients.

Cis-aconitate therapy protects against influenza mortality by dual targeting of viral polymerase and ERK/AKT/NF-κB signaling

This study identifies cis-aconitate as a dual-action antiviral and anti-inflammatory agent that reduces influenza mortality in mice by targeting viral polymerase and ERK/AKT/NF-κB signaling.

MAIT cells protect in severe pneumococcal pneumonia by regulating neutrophil/macrophage antimicrobial activities

Bona fide cytotoxic iNKT cells with superior antitumour responses identified in mice and humans

This study identifies specific iNKT cell subsets in mice and humans with enhanced antitumor activity, suggesting potential improvements for adoptive cell therapies.