PRMT5 is required for full-length HTT expression by repressing multiple proximal intronic polyadenylation sites
Mona Alqazzaz, Felipe E. Ciamponi, Jolene Caifeng Ho, Maxim I. Maron, Manisha Yadav, Aiden M. Sababi, Graham Dickson and Hugh MacLeod, Moloud Ahmadi, Garrett Bullivant, Vincent Tano, Sarah R. Langley, María Sánchez‐Osuna, Patty Sachamitr, Michelle M. Kushida, Laura M. Richards, , Panagiotis Prinos
This paper identifies PRMT5 as a regulator of HTT mRNA splicing and alternative polyadenylation, showing that its inhibition reduces full-length HTT protein levels by promoting premature termination and cleavage.
bioRxiv · Mar 14, 2024 · PreprintNeuroscience