Author

Lesley T. MacNeil

Michael G. DeGroote Institute for Infectious Disease ResearchORCID 0000-0001-9562-8754Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Developmental Biology· 1 Genetics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 3 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Victoria L. León Guerrero· 2 shared Alexander P. HynesiD· 1 shared Aline Fiebig‐ComyniD· 1 shared Allison K. GuitoriD· 1 shared Amelia Bing Ya Guo· 1 shared Andrea J. TenchiD· 1 shared Anna Floyd AveretteiD· 1 shared Bonnie YiuiD· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersGenetics

Victoria L. León Guerrero

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Author profile →

4 papers

Recent·Most cited

BiochemistryCellPeer-reviewedDec 31, 2025

Butyrolactol A potentiates caspofungin efficacy against resistant fungi via phospholipid flippase inhibition

Xuefei Chen, H. Diessel Duan, Michael J. Hoy…·Gerard D. Wright

The paper identifies butyrolactol A as a compound that enhances caspofungin efficacy against resistant fungi by inhibiting phospholipid flippase, thereby improving antifungal treatment.

20 citationstop 1%

experimental assayhost-pathogen & immune response

𝕏 PostBluesky

MicrobiologymBioPeer-reviewedAug 18, 2025

Temperate phages increase antibiotic effectiveness in a Caenorhabditis elegans infection model

Rabia Fatima, Gayatri S Nair, Jordan T. Mayol…·Alexander P. Hynes

This study shows that temperate phages can enhance antibiotic effectiveness in vivo using C. elegans, demonstrating 'temperate phage antibiotic synergy' (tPAS) by reducing phage dormancy and improving infection outcomes.

15 citationstop 2%

C. elegansbacteria (other)

𝕏 PostBluesky

GeneticsbioRxivPreprintNov 22, 2023

SHC-3: a previously unidentified C. elegans Shc family member functions in the insulin-like signaling pathway to enhance survival during L1 arrest

Victoria L. León Guerrero, Mercedes Di Bernardo, William Rod Hardy…·Lesley T. MacNeil

DOI 10.1101/2023.11.22.568309

C. elegansexperimental assay

𝕏 PostBluesky

Developmental BiologybioRxivPreprintMar 6, 2020

C. elegans ELT-3 regulates cuticle collagen expression in response to environmental stimuli

Hiva Mesbahi, Kim B. Pho, Andrea J. Tench…·Lesley T. MacNeil

The paper identifies ELT-3 as a GATA transcription factor that regulates cuticle collagen expression in C. elegans in response to environmental stimuli.

DOI 10.1101/2020.03.06.980656

C. elegansstatistical model

𝕏 PostBluesky