Rachel Lai

This study identifies a hyper-inflammatory immune response in HIV-associated TB meningitis, marked by cytotoxic CD8 T cells, activated neutrophils, and type 1 interferon signaling.

This study shows that using a human plasma-like medium enhances M. tuberculosis replication in iPSC-derived macrophages by altering lipid metabolism and organelle function.

PathIntegrate integrates multi-omics data using pathway-based modeling to identify important pathways and molecules contributing to outcomes, demonstrated on COPD and COVID-19 datasets.

This paper evaluates single-sample pathway analysis methods for metabolomics, finding that clustering-based methods offer higher precision while GSEA-based methods have better recall, and introduces two new methods with a software package.

This paper evaluates over-representation analysis (ORA) in metabolomics, showing how different parameters and datasets affect results and offering best practices for its use.