Robert John Wilkinson

The paper identifies immune signatures in TB contacts that predict protection or progression to active TB using single-cell RNA sequencing and correlates findings with non-human primate data.

This study identifies a hyper-inflammatory immune response in HIV-associated TB meningitis, marked by cytotoxic CD8 T cells, activated neutrophils, and type 1 interferon signaling.

The paper reprocesses SARS-CoV-2 genomic data to correct systematic errors in phylogenies using a novel assembly tool, resulting in a cleaner global tree of 4.47 million samples.

This paper introduces Transcript-Capture Seq to enrich bacterial mRNA from host samples, enabling analysis of the complete Mtb transcriptome in clinical samples and revealing gene expression patterns associated with in vivo bacterial activity.

This study shows M. tuberculosis can directly cross the blood-brain barrier and cause meningitis, with HIV-1 enhancing bacterial entry and BBB disruption.

This study investigates the role of PKCδ in macrophage immunomodulation during Mtb infection, finding that its deficiency leads to increased Mtb burden and exacerbated pathology.

The paper uses RNA sequencing of cerebrospinal fluid from meningitis patients to identify S. pneumoniae virulence factors, finding two genes linked to increased mortality and reduced infection persistence.

The paper identifies reduced host transcriptomic signatures for tuberculosis using microarray data and validates them with digital PCR, showing high accuracy in distinguishing TB from other conditions and latent TB.

The paper reports the first six human whole genome sequences generated and analyzed locally in South Africa, demonstrating high-quality data comparable to international standards.

GenomegaMap estimates genome-wide dN/dS ratios across 10,209 tuberculosis genomes to identify selection pressures shaping the pathogen's evolution.

ANIMA integrates clinical phenotype and microarray data to reconstruct disease endophenotypes across multiple organizational scales.