Kenton Jon Swartz

This study reports cryo-EM structures of P2X2R in lipid nanodiscs, revealing how ATP binding and lipid interactions regulate channel opening and desensitization.

The paper identifies a conserved cooling agent binding pocket in TRPM channels and shows its functional similarity between TRPM4 and TRPM8.

The paper identifies a critical residue in P2X receptor channels that influences ion permeability through lateral fenestrations.

This study shows TMC1, but not TMC2, is essential for membrane remodeling in response to calcium changes, and mutations in TMC1 disrupt membrane homeostasis, leading to hearing loss.

This study engineers RTx sensitivity in TRPV3 by mutating residues corresponding to the TRPV1 vanilloid site and shows that activation requires additional factors like pore mutations or co-agonists.