Daniela Moralli

The paper maps meiotic recombination intermediates in mice to show two repair modes that direct crossovers away from transcriptionally active genes.

The paper detects a single instance of host-to-tumour horizontal DNA transfer in canine transmissible venereal tumour, showing a 15-megabase genetic element from a dog with Middle Eastern ancestry.

The paper identifies ZCWPW1 as a protein recruited by PRDM9 to recombination hotspots and shows it is essential for meiotic double strand break repair and fertility in mice.

The paper shows that a loss-of-function variant in ZnT8 improves insulin secretion and protects against type 2 diabetes by enhancing glucose responsiveness and proinsulin conversion.

This study shows that SmcHD1 prevents TAD formation on the inactive X chromosome by altering chromatin structure and epigenetic marks.