Alexandru Radu Aricescu

Single-particle cryo-EM was used to explore the dynamic conformational landscape of three human GABAA receptor variants within the first 10 milliseconds of interaction with their neurotransmitter agonists.

This paper demonstrates that a 100 keV cryo-TEM with advanced components can achieve sub-3 Å resolution structures of various proteins and viruses.

This paper identifies NACHO as an ER-resident protein that facilitates the assembly of pentameric ligand-gated ion channels by interacting with subunit interfaces.

The paper introduces FixEL, a method to trap and image small molecules in brain tissue, enabling visualization of their distribution and dynamics.

The paper designs and characterizes CPTX, a synthetic protein that restores synaptic function and behavior in mouse models of neurological diseases.

The paper reports cryo-EM and crystal structures of GABAA receptors with ligands, revealing the molecular basis of BZD modulation.

The paper investigates PRDM9 binding and its effects on meiotic recombination and gene expression in human cells, finding that DNA-binding motifs and histone modifications predict recombination outcomes.