Author

Jens Köhler

Dana-Farber Cancer InstituteORCID 0000-0002-9922-6469Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Approach:experimental assay· 1

Frequent Co-Authors

Adrian Gerold SacheriD· 1 shared Alexander Wang YingiD· 1 shared Caitlyn Weston· 1 shared Cigall KadochiD· 1 shared Claudia Gentile· 1 shared Daren C. CardiD· 1 shared Fan ZhangiD· 1 shared Florence T.H. WuiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCancer Biology

Adrian Gerold SacherORCID

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2 papers

Recent·Most cited

mSWI/SNF complex inhibition sensitizes KRAS-mutant lung cancers to targeted therapies via epithelial-mesenchymal subversion

Claudia Gentile, William W. Feng, Sean M. Lenahan, Alexander Wang Ying, Daren C. Card, Florence T.H. Wu, Nhu‐An Pham, Nikolina Radulovich, Pinjiang Mary Cao, K. Hueniken, Quan Li, Ming‐Sound Tsao, JOSEPH S. KULESZA, Madeline M. Hinkley, Lishu Liao, , Cigall Kadoch

This study shows that inhibiting mSWI/SNF complexes enhances the effectiveness of KRAS inhibitors in lung cancers by reversing epithelial-mesenchymal transition resistance.

bioRxiv · Mar 1, 2026 · PreprintCancer Biology

Drug-driven reclassification of multiple tumour subtypes reveals intrinsic molecular concordance of therapy across histologically disparate cancers

Yue Xu, Jie Zheng, Zhaoqing Cai, Wang Li, Jens Köhler, Yao Dai, Xiaojie Cheng, Tao Wu, Fan Zhang, Haiyun Wang

This study reclassifies tumors based on drug response and genomic alterations, revealing molecular concordance in therapy across histologically different cancers.

bioRxiv · Mar 2, 2021 · PreprintBioinformatics