Katja Sträßer

The paper uses R-DeeP to show stress-induced compartment-specific RNA buffering of protein aggregation in yeast, with nuclear RNA retention protecting nuclear proteins from aggregation.

This study identifies Yra1 phosphorylation as a mechanism that inhibits bulk mRNA export during heat stress while promoting selective export of heat-induced transcripts in S. cerevisiae.

The paper shows that excess Mex67-Mtr2 in nuclear mRNPs impairs mRNA export, and overexpression of Nab2 or Yra1 suppresses this defect by reducing Mex67 levels.

The paper profiles RNA-dependent proteins in two yeast species, identifies a conserved core and species-specific adaptations, and introduces R-DeeP as a tool for RNA-protein interaction analysis.