L. Garry Adams

A Synthetic Microbial Therapy Rewires Antitumor Immunity Across Multiple Cancer Types

This paper introduces a synthetic microbial therapy that enhances antitumor immunity across multiple cancer types in mice, showing durable responses and synergy with chemotherapy.

Borrelia burgdorferi infection-enhanced Ixodes scapularis serpins S12c5 and S13c5, target MASP1/3 to inhibit MBL-pathway complement activation and promote spirochete survival

This study identifies two tick serpins, S12c5 and S13c5, that inhibit complement activation and enhance Borrelia burgdorferi survival by targeting MASP1/3.

Identification of a genetic region in linked to tolerance to MRSA infection using Collaborative Cross mice.

The paper identifies a genetic region on chromosome 7 associated with MRSA tolerance in mice by analyzing F1 and F2 populations from CC061 and CC024 crosses.

Late-life dietary folate restriction reduces biosynthetic processes without compromising healthspan in mice

This study shows that reducing folate intake in aged mice decreases biosynthetic processes but does not compromise healthspan, suggesting age-dependent benefits of folate restriction.

Precision pharmacological reversal of genotype-specific diet-induced metabolic syndrome in mice informed by transcriptional regulation

The paper uses mouse models to study diet-induced metabolic syndrome, identifies strain-specific transcriptional and epigenomic changes, and tests genotype-targeted pharmacological interventions.

Elucidating Mechanisms of Tolerance to Salmonella Typhimurium Across Long-Term Infections Using the Collaborative Cross

The paper investigates tolerance to Salmonella Typhimurium in genetically diverse mice, identifying fibrinogen genes as key candidates distinguishing tolerance from resistance.

Genetic background influences survival of infections with Salmonella enterica serovar Typhimurium in the Collaborative Cross

This study investigates the genetic basis of survival differences in Salmonella Typhimurium infections across genetically diverse Collaborative Cross mouse strains, identifying new genomic regions associated with susceptibility and survival.