Marissa A. Smail

Pediatric traumatic brain injury elicits acute neuroinflammation and long-term changes in social, cognitive, and decision-making behaviors in male and female rats

This study shows that pediatric TBI in rats leads to long-term cognitive, social, and decision-making impairments, linked to acute neuroimmune changes.

Sex-Specific Regulation of Behavioral Responses to Single Prolonged Stress: Role of PACAP

This study investigates sex-specific effects of PACAP in a PTSD model, finding differential behavioral outcomes in male and female rats following stress.

Molecular Neurobiology of Loss

This study investigates the molecular mechanisms of psychological loss in rats using a multi-omics approach, finding changes in microglia and extracellular matrix linked to impaired emotional processing.

Differential Vulnerability of Anterior Cingulate Cortex Cell-Types to Diseases and Drugs

The paper uses sn-RNAseq data to identify cell-type-specific vulnerabilities to diseases and drugs in the anterior cingulate cortex, revealing distinct patterns of disease-state and drug effects.

Cellular, molecular, and therapeutic characterization of pilocarpine-induced temporal lobe epilepsy.

The paper analyzes transcriptomic data from pilocarpine-induced temporal lobe epilepsy to identify predictive biomarkers and cellular mechanisms, revealing aberrant interactions between cell types and potential drug targets.

Persistence: Using Protein Turnover to Expand the Applications of Transcriptomics

The paper introduces 'persistence' as a metric combining protein turnover and RNA expression to improve functional insights from transcriptomics data, showing its effectiveness in schizophrenia datasets.

Similarities and dissimilarities between psychiatric cluster disorders

This study compares psychiatric disorders using pathway, cell-type, drug-target, and chromosomal analyses to identify common and distinct features across an unbiased cluster of disorders.