Joseph C. Reese

This study identifies Def1 as a cytoplasmic regulator of mRNA translation and decay by linking ribosome status to mRNA degradation through ubiquitylation.

The paper shows that the human CCR4-NOT complex suppresses pervasive transcription and retrotransposable elements by repressing transcription and stabilizing their RNAs.

The paper identifies a novel cytoplasmic function of Def1 in yeast, showing it regulates mRNA decay and synthesis rates through interactions with post-transcriptional regulators.

The paper compares BioID variants in budding yeast, identifies TurboID as the most effective, and explores the Ccr4-Not complex interactome.

The paper shows that CCR4-NOT regulates gene expression and suppresses retrotransposon activation by modulating RNA decay and KZNF gene expression.