Alexis Morrissey

This study shows that IGF2BP family proteins suppress RNA-sensing pathways by binding TNFAIP3 mRNA, reducing innate immune signaling in AML cells.

This study investigates regulatory turnover in human segmental duplications using T2T genome assembly and ChIP-seq data, finding that regulatory elements are rarely conserved but gene expression and spatial proximity are preserved.

The paper shows that the human CCR4-NOT complex suppresses pervasive transcription and retrotransposable elements by repressing transcription and stabilizing their RNAs.

The paper shows that CCR4-NOT regulates gene expression and suppresses retrotransposon activation by modulating RNA decay and KZNF gene expression.

Allo improves regulatory element analysis in repetitive regions by accurately allocating multi-mapped reads, leading to the discovery of new peaks and interactions in ChIP-seq data.

The paper investigates how sequence preferences and chromatin environments influence Fox TF binding using neural networks and mouse stem cells.

A CRISPR screen identifies ZBTB11 and ZFP131 as factors maintaining pluripotency by pausing POL II at pro-differentiation genes.