Istvan U. Albert

Degradation factor 1, Def1, regulates mRNA translation and decay through Ccr4-Not-dependent ubiquitylation of the ribosome.

This study identifies Def1 as a cytoplasmic regulator of mRNA translation and decay by linking ribosome status to mRNA degradation through ubiquitylation.

Human CCR4-NOT suppresses pervasive transcription and retrotransposable elements

The paper shows that the human CCR4-NOT complex suppresses pervasive transcription and retrotransposable elements by repressing transcription and stabilizing their RNAs.

Epigenetic modifiers to treat retinal degenerative diseases

The paper tests chromatin condensation inhibitors in a retinal degeneration mouse model, showing they preserve retinas through different mechanisms.

Direct testing of natural twister ribozymes from over a thousand organisms reveals a broad tolerance for structural imperfections

The paper tests over 2,600 natural twister ribozymes using CHiTA, finding 94% are active and showing structural tolerance.

Human CCR4-NOT globally regulates gene expression and is a novel silencer of retrotransposon activation

The paper shows that CCR4-NOT regulates gene expression and suppresses retrotransposon activation by modulating RNA decay and KZNF gene expression.

The clock gene Per1 expression may exert diurnal control over hippocampal memory consolidation

This study identifies Per1 as a circadian gene that modulates memory consolidation in the dorsal hippocampus, showing diurnal effects on long-term memory performance in mice.