The paper investigates how centrosome architecture and m6A-dependent regulation influence p53 surveillance after whole-genome doubling, identifying key molecular mechanisms.

bioRxiv · Feb 25, 2026 · PreprintCell Biology

Polysomal profiling coupled to allele-specific proteomics reveals an EIF4H tranSNP allele possessing higher mRNA translation potential.

Meriem Hadjer Hamadou, Laura Alunno, Daniele Peroni, Michael Pancher, Fabio Mazza, Tecla Venturelli, Romina Belli, Erik Dassi, Alessandro Romanel, Alberto Inga

Molecular & Cellular Proteomics · Feb 20, 2026Peer-reviewedGenetics

A TranSNP in the DDIT4 mRNA can impact its translation efficiency and modulate p53-dependent responses in cancer cells

Meriem Hadjer Hamadou, Laura Alunno, Tecla Venturelli, Samuel Valentini, Davide Dalfovo, Francesca Lorenzini, Alessia Mattivi, Vincenza Vigorito, Glenda Paola Grupelli, Alessandro Mattè, Pamela Gatto, Michael Pancher, Chiara Valentini, Veronica De Sanctis, Roberto Bertorelli, , Alberto Inga

The paper identifies a tranSNP in DDIT4 mRNA that affects translation efficiency and modulates p53-dependent responses in cancer cells.

bioRxiv · Apr 2, 2025 · PreprintMolecular Biology

The RNA helicase DHX30 coordinates cytoplasmic translation and mitochondrial function contributing to cancer cell survival

Bartolomeo Bosco, Annalisa Rossi, Dario Rizzotto, Meriem Hadjer Hamadou, Alessandra Bisio, Sebastiano Giorgetta, Alicia Perzolli, Francesco Bonollo, Angéline Gaucherot, Frédéric Catez, Jean‐Jacques Diaz, Erik Dassi, Alberto Inga

This paper shows DHX30 coordinates cytoplasmic and mitochondrial translation, affecting cancer cell survival and prognosis through a 15-gene signature.

Cancers · Aug 31, 2021Peer-reviewedMolecular Biology

The pseudouridine synthase dyskerin binds to cytoplasmic H/ACA-box snoRNA retaining transcripts affecting nuclear hormone receptor dependence

Federico Zacchini, Giulia Venturi, Veronica De Sanctis, Roberto Bertorelli, Claudio Ceccarelli, Donatella Santini, Mario Taffurelli, Marianna Penzo, Davide Treré, Alberto Inga, Erik Dassi, Lorenzo Montanaro

The paper identifies dyskerin's role in regulating mRNA expression and nuclear hormone receptor dependence through snoRNA-retaining transcripts in breast cancer.

bioRxiv · Jan 21, 2021 · PreprintMolecular Biology

SMN-primed ribosomes modulate the translation of transcripts related to Spinal Muscular Atrophy

Fabio Lauria, Paola Bernabò, Toma Tebaldi, Ewout J. N. Groen, Elena Perenthaler, Federica Maniscalco, Annalisa Rossi, Deborah Donzel, Massimiliano Clamer, Marta Marchioretto, Neža Omersa, Julia Orri, Mauro Dalla Serra, Gregor Anderluh, Alessandro Quattrone, , Gabriella Viero

The paper shows SMN protein binds ribosomes and modulates translation of specific mRNAs in SMA, causing translational defects in motor neuron-related proteins.

Nature Cell Biology · Sep 21, 2020Peer-reviewedNeuroscience

p53-induced apoptosis is specified by a translation program regulated by PCBP2 and DHX30.

Dario Rizzotto, Sara Zaccara, Annalisa Rossi, Matthew D. Galbraith, Zdeněk Andrysík, Ahwan Pandey, Kelly D. Sullivan, Alessandro Quattrone, Joaquin Maximiliano Espinosa, Erik Dassi, Alberto Inga

This study identifies a translational control mechanism regulated by PCBP2 and DHX30 that determines the outcome of p53 activation by Nutlin, shifting the response from cell cycle arrest to apoptosis.

Cell Reports · Mar 1, 2020Peer-reviewedMolecular Biology