Tumor-expressed SPPL3 supports innate anti-tumor immune responses.
Tamara Verkerk, Antonius A. de Waard, Sofie J. I. Koomen, Jasper Sanders, Tineke Jorritsma, Anouk T. Pappot, Nordin D. Zandhuis, Tao Zhang, Manfred Wuhrer, Arie Johan Hoogendijk, Floris P. J. van Alphen, Maartje van den Biggelaar, Hannes S. J. Stockinger, Klaas P. J. M. van Gisbergen, Robbert M. Spaapen, S. Marieke van Ham
This study shows that SPPL3 in tumor cells affects innate immune responses by modulating nsGSLs, reducing susceptibility to neutrophils, NK cells, and γδ T cells.
European Journal of Immunology · Dec 10, 2024Peer-reviewedImmunology