Arie Johan Hoogendijk

Proteomics of human cancer-associated T cells identifies regulators of T cell functionality

The paper identifies proteomic regulators of T cell functionality in cancer using proteomic and transcriptomic profiling of tumor-infiltrating T cells.

Transcriptome-Proteome analysis of human naive and memory B cell subsets reveal isotype and subclass-specific phenotypes

The paper analyzes transcriptome and proteome data of human naive and memory B cells to identify isotype-specific phenotypes, finding distinct expression profiles in IgG4-switched B cells.

An early mTOR-dependent window during human T cell activation programs T cell state

This study identifies an early mTOR-dependent window during human T cell activation that programs cytotoxic fate or memory-like state, with transient inhibition promoting memory while preserving effector functions.

Mapping the dynamic RNA binding proteome in human effector T 1 cells identifies differentiation and cytotoxicity regulators

The paper maps dynamic RNA-binding proteins in human effector T cells and identifies TUT1 and SF3A1 as regulators of differentiation and cytotoxicity.

mTOR signaling promotes cytokine production in T cells through 3UTR-mediated translation control

This study identifies a novel mTOR-dependent mechanism regulating cytokine production in T cells through 3UTR AU-rich elements and DDX21 binding.

Proximity labeling reveals ZFP36L1 as a central hub for post-transcriptional regulation networks in T cells

The paper maps the ZFP36L1 interactome in human T cells using proximity labeling, revealing its role in post-transcriptional regulation and protein expression.

Combined deletion of ZFP36L1 and ZFP36L2 drives superior cytokine production in T cells at the cost of cell fitness

This study shows that deleting both ZFP36L1 and ZFP36L2 in T cells greatly increases cytokine production but reduces cell viability and signaling.

Tumor-expressed SPPL3 supports innate anti-tumor immune responses.

This study shows that SPPL3 in tumor cells affects innate immune responses by modulating nsGSLs, reducing susceptibility to neutrophils, NK cells, and γδ T cells.