Silke Meiners

This study shows SARS-CoV-2 E-protein activates CD8+ T cells in mouse lungs via TLR2, observed using intravital microscopy and ex vivo stimulation.

This study shows that local IFNγ signaling in aged lungs impairs alveolar progenitor cell regeneration, and reducing IFNγ levels restores regenerative capacity.

This study shows PA200 regulates proteasome composition and inhibits cancer cell migration, with cell-specific effects on integrin and ECM regulators.

This paper reveals structural and functional differences in PA200 interaction with the immunoproteasome (i20S) compared to the standard proteasome (s20S), showing PA200 enhances i20S activation and regulates its gene expression.