Author

Yechun Xu

Chinese Academy of SciencesORCID 0000-0002-1581-6155Unclaimed ORCID profile · follow to get notified of new preprints

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Yechun Xu2 papers · Chinese Academy of Sciences

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:virus· 2 Approach:deep learning· 1 Assay:protein structure· 1 Assay:structural biology· 1

Frequent Co-Authors

Wenfeng ZhaoiD· 2 shared Chang‐Qiang Ke· 1 shared Fang BaiiD· 1 shared Haixia SuiD· 1 shared Hang XieiD· 1 shared Hangchen HuiD· 1 shared Hong Shu LiuiD· 1 shared Hualiang JiangiD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

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10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

Wenfeng ZhaoORCID

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2 papers

Recent·Most cited

BiochemistryJournal of the American Chemical SocietyPeer-reviewedNov 22, 2024

Covalent DNA-Encoded Library Workflow Drives Discovery of SARS-CoV-2 Non-structural Proteins Inhibitors

Xudong Wang, Liwei Xiong, Ying Zhu…·Xiaojie Lu

This study uses covalent DNA-encoded libraries to discover inhibitors targeting SARS-CoV-2 proteases 3CLpro and PLpro, identifying novel compounds with potent activity and unique binding modes.

34 citationstop 1%

virusstructural biology

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Molecular BiologybioRxivPreprintApr 13, 2020

✦ In-depth digest

Discovery of baicalin and baicalein as novel, natural product inhibitors of SARS-CoV-2 3CL protease in vitro

Haixia Su, Sheng Yao, Wenfeng Zhao…·Yechun Xu

Baicalin and baicalein from Scutellaria baicalensis inhibit SARS-CoV-2 3CL protease non-covalently; a 2.2 Å baicalein complex structure shows an unusual shield-like binding mode.

143 citations

virusprotein structure

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