Author

Noelle V. Frey

Abramson Cancer CenterORCID 0000-0003-3688-9836Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Assay:CITE-seq· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Stephan A. GruppiD· 2 shared Aditi ChandraiD· 1 shared Alexander J. DimitriiD· 1 shared Alexander T. DilsiD· 1 shared Alexandra NeeseriD· 1 shared Amy E. BaxteriD· 1 shared Anna M. RomanoviD· 1 shared Austin Cozzone· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBioengineering

Stephan A. GruppORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

BioengineeringNature Biomedical EngineeringPeer-reviewedAug 25, 2025

Directed evolution-based discovery of ligands for in vivo restimulation of CAR-T cells

Tomasz M. Grzywa, Alexandra Neeser, Ranjani Ramasubramanian…·Darrell J. Irvine

This study develops a method to generate optimized peptide ligands for CAR-T cell restimulation, demonstrating enhanced expansion and memory development in preclinical models.

8 citations

mouseexperimental assay

𝕏 PostBluesky

ImmunologyScience AdvancesPeer-reviewedNov 13, 2024

TET2 regulates early and late transitions in exhausted CD8+ T-cell differentiation and limits CAR T-cell function

Alexander J. Dimitri, Amy E. Baxter, Gregory M. Chen…·Joseph A. Fraietta

This study shows that targeting TET2 in CAR T-cells improves their anti-tumor responses by limiting terminal exhaustion and enhancing therapeutic potential.

42 citationstop 2%

mouseCITE-seq

𝕏 PostBluesky