Carlos A. Saura

This study investigates how β-amyloid and tau pathologies affect different neural circuits in a novel Alzheimer's disease mouse model, revealing region-specific synaptic, behavioral, and molecular changes.

The paper identifies CREB/CRTC1-regulated gene programs that link synaptic activity to transcriptional control of NMDA receptor-mediated plasticity and memory in hippocampal neurons.

This study shows that Nr4a2 activation prevents oAβ-induced synaptic dysfunction and memory deficits in AD mouse models.

This study investigates how presenilin dysfunction affects tau pathology through autophagy and proteasome pathways in familial Alzheimer's disease.

The paper shows that spatial memory training in APPSw,Ind mice reverses Aβ-induced reductions in hippocampal GirK2 and SNX27 expression, suggesting a potential therapeutic approach for early AD.