Differential neural circuit vulnerability to β-amyloid and tau pathologies in novel Alzheimer disease mice
Maria Dolores Capilla-López, Ángel Deprada-Fernandez, Yuniesky Andrade‐Talavera, Irene Martínez‐Gallego, Heriberto Coatl-Cuaya, Paula Sotillo Sotillo, José Rodrı́guez-Álvarez, Antonio Rodríguez Moreno, Arnaldo Parra‐Damas, Carlos A. Saura
This study investigates how β-amyloid and tau pathologies affect different neural circuits in a novel Alzheimer's disease mouse model, revealing region-specific synaptic, behavioral, and molecular changes.
Molecular Psychiatry · Jan 30, 2025Peer-reviewedNeuroscience