Lydia Jiménez‐Díaz

The paper screens over one million compounds to identify GIRK2-PIP2 modulators using docking, MM-GBSA, ADMET, and molecular dynamics.

This study shows that activating sigma-1 receptors with PRE-084 rescues synaptic plasticity and memory impairments caused by amyloid-beta oligomers in an Alzheimer's disease model.

The paper tests a GIRK channel activator in AD models, finding low doses improve synaptic plasticity and memory without sex differences, while high doses impair function in healthy mice.

The paper maps spatial proteomic changes in dorsal and ventral hippocampus of male and female Alzheimer's disease models, identifying sex-dependent protein alterations linked to synaptic plasticity and GSK-3β activity.

This study shows that beta-hydroxybutyrate (BHB) improves AMPA receptor levels and cognitive performance in mice exposed to a high-fat diet.

The paper shows that blocking GIRK activity disrupts hippocampal oscillations and converts LTP to LTD, leading to pathological oscillations.

This study characterizes the effects of Aβ1-42 injection on memory and synaptic plasticity in male and female mice, finding long-lasting impairments in both sexes.

The paper shows that spatial memory training in APPSw,Ind mice reverses Aβ-induced reductions in hippocampal GirK2 and SNX27 expression, suggesting a potential therapeutic approach for early AD.

This study shows that modulating basal GirK channel activity in the dorsal hippocampus affects synaptic plasticity and cognitive functions by altering neural excitability and long-term plasticity processes.