Ana Contreras

Low dose of a non-urea selective GIRK channel activator improves hippocampal-dependent synaptic plasticity and memory disrupted by amyloid-β oligomers

The paper tests a GIRK channel activator in AD models, finding low doses improve synaptic plasticity and memory without sex differences, while high doses impair function in healthy mice.

Mapping the spatial proteomic signature of dorsal and ventral hippocampus in a mouse model of early Alzheimer's disease: changes in synaptic plasticity-related proteins associated with sexual dimorphism

The paper maps spatial proteomic changes in dorsal and ventral hippocampus of male and female Alzheimer's disease models, identifying sex-dependent protein alterations linked to synaptic plasticity and GSK-3β activity.

Impairments in hippocampal oscillations accompany the loss of LTP induced by GIRK activity blockade

The paper shows that blocking GIRK activity disrupts hippocampal oscillations and converts LTP to LTD, leading to pathological oscillations.

Systematic characterization of a non-transgenic Aβ1-42 amyloidosis model: synaptic plasticity and memory deficits in female and male mice

This study characterizes the effects of Aβ1-42 injection on memory and synaptic plasticity in male and female mice, finding long-lasting impairments in both sexes.

Spatial memory training reverses GirK channels modulation in the transgenic APPSw,Ind Alzheimer's disease mouse model

The paper shows that spatial memory training in APPSw,Ind mice reverses Aβ-induced reductions in hippocampal GirK2 and SNX27 expression, suggesting a potential therapeutic approach for early AD.

Alterations in leptin signaling in Amyotrophic Lateral Sclerosis (ALS)

The paper investigates leptin signaling alterations in ALS by analyzing mRNA, protein expression, and plasma levels in TDP-43A315T mice compared to WT controls.