David Paul Toczyski

This study identifies FBXO42's role in regulating PPP4C and p53 signaling, showing its importance in cancer cell survival through genetic and proteomic analyses.

The paper identifies BCL2 proteins as co-receptors for CUL5WSB2 to target BIM for degradation, revealing a novel mechanism in apoptosis regulation with therapeutic implications for neuroblastomas and cancers.

The paper identifies PRC2.1's role in opposing G1 progression by regulating CCND1 and CCND2, showing its importance in cell proliferation across multiple cancer types.

This paper identifies Isr1 as a negative regulator of the hexosamine biosynthesis pathway in yeast, showing it inhibits Gfa1 and modulates UDP-GlcNAc synthesis in response to cell cycle and nutrient signals.

The paper shows that subtelomeric sequences in S. pombe are hyper-recombinogenic and have unstable nucleosomes, with Ccq1 protecting them through heterochromatic repression.