ImmunologybioRxivPreprint
Targeting peptide-MHC complexes with designed T cell receptors and antibodies
Amir Motmaen, Kevin M. Jude, Nan Wang…·Philip H Bradley
This paper introduces ADAPT, a deep learning framework for designing TCRs and antibodies that bind to specific pMHC targets, validated through cryo-EM structures and functional testing.
6 citations