Anastasia A. Minervina

This study shows that HIV-1 DNA/rAd5 vaccination leads to distinct clonal expansion and memory precursor states in Env- and Gag-specific CD8 T cells.

TCR2HLA infers HLA genotypes from TCR repertoires, enabling identification of immunologically relevant metaclonotypes and discovery of HLA-associated TCRs.

TIRTL-seq provides a scalable, cost-effective method for paired TCR repertoire sequencing, enabling accurate identification of TCR chain pairings and clonotype dynamics in large cohorts.

This paper introduces ADAPT, a deep learning framework for designing TCRs and antibodies that bind to specific pMHC targets, validated through cryo-EM structures and functional testing.

This paper introduces a computational method to predict TCR-pMHC interactions and design immunogenic peptides, achieving high accuracy and demonstrating success in T-cell activation.

The paper analyzes 6 million T cells from 91 studies to identify TCR sequence convergence patterns and their association with functional and cellular T cell phenotypes.

This study compares neonatal and adult CD8+ recent thymic emigrants using single-cell multiomics, finding distinct phenotypes and functions despite similar post-thymic maturation.

The paper develops a model to predict HLA types from TCR repertoires using associations inferred from HLA-typed donors.

This paper introduces copepodTCR, a tool for designing and interpreting TCR specificity assays, which efficiently identifies antigen-specific TCRs using combinatorial peptide pooling and Bayesian modeling.

This study demonstrates that immune repertoires can uniquely identify individuals with high accuracy using a classifier based on repertoire similarity.

This study develops a normalization procedure to enhance detection of rare somatic retroelement insertions in sequencing libraries, increasing identified insertions by 7.9-fold.