Author

Isabelle R. Gordon

Washington University in St. LouisORCID 0000-0003-3714-7789Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Alexander G. ChamessianiD· 1 shared Alexander M. Barclay· 1 shared Brock T. SummersiD· 1 shared Chad M. RienstraiD· 1 shared Charles D. SchwietersiD· 1 shared Collin G. BorcikiD· 1 shared Deborah A. Berthold· 1 shared Dhruva D. DhavaleiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperNeuroscience

Alexander G. ChamessianORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintJan 21, 2025

Small molecule-mediated targeted protein degradation of voltage-gated sodium channels involved in pain

Alexander G. Chamessian, Maria Payne, Isabelle R. Gordon…·Robert W. Gereau

This study investigates the use of small molecule degraders to target voltage-gated sodium channels NaV1.8 and NaV1.7, showing their degradation via PROTACs and molecular glues involving CRBN and VHL.

6 citations

experimental assay

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NeuroscienceNature CommunicationsPeer-reviewedMar 29, 2024

Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue

Dhruva D. Dhavale, Alexander M. Barclay, Collin G. Borcik…·Paul T. Kotzbauer

This study determines the atomic structure of alpha-synuclein fibrils from Lewy body dementia tissue using a novel amplification method and solid-state NMR.

73 citationstop 1%

humanprotein structure

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