Jan Mulder

This paper maps dementia risk genes across tissues and cell types using HPA GeneSet Explorer, revealing convergent neuronal enrichment and disease-specific modules in Alzheimer's, Lewy body, and Frontotemporal dementias.

The paper shows reduced CCT2 and CCT3 levels stratify Alzheimer's disease, with CCT3 localized to astrocytes and linked to oxidative stress and beta-amyloid accumulation.

This study creates spatiotemporal transcriptomic maps of mouse brain after ICH to understand cellular responses and identify therapeutic targets.

The paper constructs a multimodal brain cell atlas of adult macaques across their lifespan, revealing aging-related molecular changes and identifying aging hotspots and regulatory loci.

The paper identifies microglial states associated with lesion expansion and remyelination in multiple sclerosis using spatial transcriptomics on human brain tissue.

The paper examines changes in substance P, NPY, and their receptors in major depression by analyzing transcript levels in brain regions of suicide victims and controls.

The paper annotates all human protein-coding genes with their function and spatial distribution across cell types using single-cell transcriptomics data and introduces a new classification tool.

The paper maps and characterizes the human secretome by annotating 2,623 predicted secreted proteins and their spatial distribution, using a high-throughput cell factory for recombinant protein production and analysis.