Inge Huitinga

The paper integrates genotype, clinical, and neuropathological data from 2,553 donors to show genetic risk overlaps across brain disorders and neuropsychiatric symptoms.

The paper identifies reduced triacylglycerols and lipid droplets in resilient Alzheimer's donors compared to AD patients, using multi-omics analysis of brain tissue.

The paper identifies foamy microglia as contributors to disease progression in secondary progressive MS, linking oxylipins to lesion expansion and proposing monoacylglycerol lipase as a therapeutic target.

The paper introduces fluorescent activity-based probes to map MAGL activity in brain tissues, revealing its spatial distribution in mouse and human brains.

The paper identifies microglial states associated with lesion expansion and remyelination in multiple sclerosis using spatial transcriptomics on human brain tissue.

The paper examines microglia nodules in multiple sclerosis and finds they are associated with higher lesion load and specific gene expression changes compared to stroke.

The paper examines connectivity principles at micro- and macroscales in the human brain, finding similar organizational patterns in dendritic and white matter structures.

The paper compares myelin proteome and oligodendrocyte transcriptome profiles between humans and mice, finding both conservation and divergence in specific proteins and genes.

The paper investigates complement system involvement in synapse loss in MS hippocampus, finding C1q deposits linked to inhibitory synapse loss and impaired memory.

The paper uses spatial transcriptomics and in situ sequencing to study gene networks in the amyloid-β plaque niche of AD, revealing microglia-astroglia interactions and myelination abnormalities.